The Blues are heavy favourites to reach the FA Cup semi-finals and will be expected to book another trip to Wembley.
But defeat would turn up the pressure on Pochettino and leave Chelsea with little play for this season.
This is a repeat of the 2021 FA Cup Final, which Leicester won 1-0.
Here’s everything you need to know about the game.
Date, kick-off time and venue
Chelsea vs Leicester is scheduled for a 12.45pm GMT kick-off time on Sunday 17 March, 2024.
Stamford Bridge in London will host.
Where to watch Chelsea vs Leicester
TV channel: The game will be broadcast on free-to-air television in the UK. Coverage starts on BBC One at 12.20pm GMT ahead of a 12.45pm kick-off.
Live stream: The BBC Sport website and BBC iPlayer will each offer a free live stream service.
Live blog: Follow all the action with Standard Sport’s dedicated match blog! Nizaar Kinsella will be providing expert analysis from the ground.
Chelsea vs Leicester team news
Enzo Fernandez is suspended, meaning Mykhailo Mudryk could come into the XI.
Chilwell has picked up another injury
Chelsea FC via Getty Images
Leicester boss Enzo Maresca has confirmed an injury to Jamie Vardy will keep him out of the trip to London.
Kasey McAteer and Ricardo Pereira have also been ruled out and Wilfred Ndidi is managing a nagging issue, with the Foxes vowing to play their strongest team.
Chelsea vs Leicester prediction
It may not be totally convincing but Chelsea should have enough to beat a Championship side with focus elsewhere.
Head to head (h2h) history and results
Chelsea vs Leicester latest odds
Chelsea to go through: 2/9
Leicester to go through: 3/1
Odds via Bet365 and subject to change.